The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like.

@article{BaenaLopez2008TheTS,
  title={The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like.},
  author={Luis Alberto Baena-Lopez and Isabel Rodr{\'i}guez and Antonio Baonza},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 28},
  pages={9645-50}
}
The activity of different signaling pathways must be precisely regulated during development to define the final size and pattern of an organ. The Drosophila tumor suppressor genes dachsous (ds) and fat (ft) modulate organ size and pattern formation during imaginal disc development. Recent studies have proposed that Fat acts through the conserved Hippo signaling pathway to repress the expression of cycE, bantam, and diap-1. However, the combined ectopic expression of all of these target genes… CONTINUE READING
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