The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control.

@article{Sard1999TheTG,
  title={The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control.},
  author={Laura Sard and Paola Accornero and Silvana Tornielli and Domenico Delia and G Bunone and Manuela Campiglio and M. P. Colombo and Marcella Gramegna and Carlo M. Croce and Marco Alessandro Pierotti and Gabriella Sozzi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 15},
  pages={8489-92}
}
Alteration of the FHIT (fragile histidine triad) gene occurs as an early and frequent event in lung carcinogenesis. FHIT gene transfer into lung cancer cell line H460 lacking Fhit protein expression resulted in reversion of tumorigenicity. To gain insight into the biological function of FHIT, we compared the H460 cell line with its Fhit transfectants (H460/FHIT). A significant inhibition of cell growth was observed in H460/FHIT cells. The analysis of apoptosis by in situ terminal… CONTINUE READING