The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle.

@article{Qiu2008TheTS,
  title={The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle.},
  author={Guo-Hua Qiu and Manuel Salto-Tellez and James Alexander Ross and Winnie Yeo and Penggang Liu and Nicholas Wheelhouse and George Gong Chen and David H.T. Harrison and Paul Lai and Qian Tao and Shing Chuan Hooi},
  journal={Journal of hepatology},
  year={2008},
  volume={48 3},
  pages={433-41}
}
BACKGROUND/AIMS The chromosome locus 3p21.3 is a "hot-spot" for chromosomal aberrations and loss of heterozygosity in cancers. The 35 genes mapped to the AP20 subregion of this locus were screened for their expression to identify candidate tumor suppressor genes. DLEC1 was selected for further characterization in primary hepatocellular carcinomas and cell lines. METHODS RT-PCR and methylation-specific PCR were performed to examine the expression and methylation. Stable clones with DLEC1… CONTINUE READING
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