The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus

@article{Petit2004TheTS,
  title={The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus},
  author={Marleen M R Petit and Sandra M. P. Meulemans and Philippe Alen and Torik A. Y. Ayoubi and E C L Jansen and Wim J. M. Van de Ven},
  journal={BMC Cell Biology},
  year={2004},
  volume={6},
  pages={1 - 1}
}
At sites of cell adhesion, proteins exist that not only perform structural tasks but also have a signaling function. Previously, we found that the Lipoma Preferred Partner (LPP) protein is localized at sites of cell adhesion such as focal adhesions and cell-cell contacts, and shuttles to the nucleus where it has transcriptional activation capacity. LPP is a member of the zyxin family of proteins, which contains five members: ajuba, LIMD1, LPP, TRIP6 and zyxin. LPP has three LIM domains (zinc… CONTINUE READING