The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase.

@article{Wang2000TheTS,
  title={The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase.},
  author={Xiaodong Wang and Anette Gj{\"o}rloff-Wingren and Mansi Saxena and Nuzhat I. Pathan and John C. Reed and Tomas M. Mustelin},
  journal={Journal of immunology},
  year={2000},
  volume={164 4},
  pages={1934-9}
}
The tumor suppressor gene PTEN encodes a 55-kDa enzyme that hydrolyzes both protein phosphotyrosyl and 3-phosphorylated inositol phospholipids in vitro. We have found that the latter activity is physiologically relevant in intact T cells. Expression of active PTEN lead to a 50% loss of transfected cells due to increased apoptosis, which was completely prevented by coexpression of a constitutively active, membrane-bound form of protein kinase B. A mutant of PTEN selectively lacking lipid… CONTINUE READING

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