The tumor suppressive role of miRNA-370 by targeting FoxM1 in acute myeloid leukemia

@inproceedings{Zhang2012TheTS,
  title={The tumor suppressive role of miRNA-370 by targeting FoxM1 in acute myeloid leukemia},
  author={Xiaolu Zhang and Jiping Zeng and Minran Zhou and Bingnan Li and Yuanyuan Zhang and Tao Huang and Lixiang Wang and Jihui Jia and Chun-yan Chen},
  booktitle={Molecular Cancer},
  year={2012}
}
Recent evidence has accumulated that MicroRNA (miRNA) dysregulation occurs in the majority of human malignancies including acute myeloid leukemia (AML) and may contribute to onco-/leukemo-genesis. The expression levels of miR-370 and FoxM1 were assessed in 48 newly diagnosed AML patients, 40 AML patients in 1st complete remission (CR) and 21 healthy controls. Quantitative real-time PCR, western blots, colony formation assay, and β-Galactosidase ( SA- β-Gal) staining were used to characterize… CONTINUE READING