The tumor spectrum in FHIT-deficient mice.

  title={The tumor spectrum in FHIT-deficient mice.},
  author={Nicola Zanesi and Vincenzo Fidanza and Louise Y. Fong and Roberta Mancini and Teresa Druck and Mauro Valtieri and Thomas Ruediger and Peter A. McCue and Carlo M. Croce and Kay F Huebner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={98 18},
Mice carrying one inactivated Fhit allele (Fhit +/- mice) are highly susceptible to tumor induction by N-nitrosomethylbenzylamine, with 100% of Fhit +/- mice exhibiting tumors of the forestomach/squamocolumnar junction vs. 25% of Fhit +/+ controls. In the current study a single N-nitrosomethylbenzylamine dose was administered to Fhit +/+, +/-, and -/- mice to compare carcinogen susceptibility in +/- and -/- Fhit-deficient mice. At 29 weeks after treatment, 7.7% of wild-type mice had tumors. Of… CONTINUE READING


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