The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation.

@article{Pogribny2009TheTA,
  title={The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation.},
  author={Igor P Pogribny and Levan Muskhelishvili and Volodymyr P. Tryndyak and Frederick A Beland},
  journal={Toxicology and applied pharmacology},
  year={2009},
  volume={235 3},
  pages={305-11}
}
The aromatic amine 2-acetylaminofluore (2-AAF) is a powerful complete genotoxic rat liver carcinogen that induces tumors without any additional interventions. While the tumor-initiating genotoxic activity of 2-AAF is well established, its tumor-promotion activity is far less understood. It is believed that the tumor-promoting property of 2-AAF is associated with selective enhancement of cell replication and sustained suppression of apoptosis in initiated cells. In the present study, we… CONTINUE READING

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