The tumor necrosis factor-alpha AU-rich element inhibits the stable association of the 40S ribosomal subunit with RNA transcripts.

@article{Wax2005TheTN,
  title={The tumor necrosis factor-alpha AU-rich element inhibits the stable association of the 40S ribosomal subunit with RNA transcripts.},
  author={Stephen D Wax and Hideki Nakamura and Paul Anderson},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={333 4},
  pages={1100-6}
}
Tumor necrosis factor-alpha (TNF-alpha) is a potent cytokine that is central to normal immune responses as well as autoimmune inflammatory diseases. The production of TNF-alpha protein is thus tightly regulated at multiple levels. Translational control is one of the means by which TNF-alpha production is repressed in unstimulated cells. To examine the mechanism by which the translation of TNF-alpha mRNA transcripts is repressed, we have used an in vitro translation system. The AU-rich element… CONTINUE READING