The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma.

@article{Cooper2012TheTM,
  title={The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma.},
  author={Lee A. D. Cooper and David A. Gutman and Candace Chisolm and Christina Appin and Jun Kong and Yuan Rong and Tahsin M. Kurç and Erwin G Van Meir and Joel H. Saltz and Carlos S. Moreno and Daniel J. Brat},
  journal={The American journal of pathology},
  year={2012},
  volume={180 5},
  pages={
          2108-19
        }
}
The Cancer Genome Atlas (TCGA) project has generated gene expression data that divides glioblastoma (GBM) into four transcriptional classes: proneural, neural, classical, and mesenchymal. Because transcriptional class is only partially explained by underlying genomic alterations, we hypothesize that the tumor microenvironment may also have an impact. In this study, we focused on necrosis and angiogenesis because their presence is both prognostically and biologically significant. These features… CONTINUE READING

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