The tubulovesicular structures - the ultrastructural hallmark for all prion diseases.

@article{Liberski2008TheTS,
  title={The tubulovesicular structures - the ultrastructural hallmark for all prion diseases.},
  author={Pawel P. Liberski},
  journal={Acta neurobiologiae experimentalis},
  year={2008},
  volume={68 1},
  pages={113-21}
}
Tubulovesicular structures (particles - TVS) are the only ultrastructural marker for all prion diseases as seen by thin-section electron microscopy as opposed to "negative-staining" techniques. TVS are spheres or short rods of approximately 27 nm in diameter. That size of TVS is also the size of filter cut-off of infectivity as judged from the ultrafiltration studies and the size of the smallest infectious unit as recently estimated. TVS have been found in all naturally occurring and… CONTINUE READING