The tubulin code: Molecular components, readout mechanisms, and functions

@inproceedings{Janke2014TheTC,
  title={The tubulin code: Molecular components, readout mechanisms, and functions},
  author={Carsten Janke},
  booktitle={The Journal of cell biology},
  year={2014}
}
Microtubules are cytoskeletal filaments that are dynamically assembled from α/β-tubulin heterodimers. The primary sequence and structure of the tubulin proteins and, consequently, the properties and architecture of microtubules are highly conserved in eukaryotes. Despite this conservation, tubulin is subject to heterogeneity that is generated in two ways: by the expression of different tubulin isotypes and by posttranslational modifications (PTMs). Identifying the mechanisms that generate and… CONTINUE READING
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