The trypanocidal benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2).

Abstract

Oxidative stress is a frequent cause underlying drug-induced hepatotoxicity. Benznidazole (BZL) is the only trypanocidal agent available for treatment of Chagas disease in endemic areas. Its use is associated with side effects, including increases in biomarkers of hepatotoxicity. However, BZL potential to cause oxidative stress has been poorly investigated… (More)
DOI: 10.1016/j.taap.2016.05.007

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Cite this paper

@article{Rigalli2016TheTB, title={The trypanocidal benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2).}, author={Juan Pablo Rigalli and Virginia Gabriela Perdomo and Nadia Ciriaci and Daniel Eleazar Antonio Franc{\'e}s and Mar{\'i}a Teresa Ronco and Amy Michele Bataille and Carolina In{\'e}s Ghanem and Mar{\'i}a Laura Ruiz and Jos{\'e} Enrique Manautou and Viviana Alicia Catania}, journal={Toxicology and applied pharmacology}, year={2016}, volume={304}, pages={90-8} }