The trouble with circadian clock dysfunction: Multiple deleterious effects on the brain and body
@article{Zelinski2014TheTW, title={The trouble with circadian clock dysfunction: Multiple deleterious effects on the brain and body}, author={Erin L. Zelinski and Scott H. Deibel and Robert J. McDonald}, journal={Neuroscience \& Biobehavioral Reviews}, year={2014}, volume={40}, pages={80-101} }
161 Citations
Circadian Rhythm: Enhancing Brain Synchronization and Cognition
- Biology, Psychology
- 2021
The physiological basis of these responses and the influence of various lighting environments on cognitive processes are summarized here, taking into account their effects on circadian rhythms, sleep and arousal.
Photoperiod-Induced Neuroplasticity in the Circadian System
- Biology, PsychologyNeural plasticity
- 2018
Various forms of neuroplasticity that occur in theSCN and other brain regions to facilitate seasonal adaptation are explored, particularly altered phase distribution of cellular circadian oscillators in the SCN and changes in hypothalamic neurotransmitter expression.
The circadian hippocampus and its reprogramming in epilepsy: impact for chronotherapeutics
- Biology, PsychologybioRxiv
- 2017
The hippocampus, and perhaps other cortical regions, shows a daily remapping of its molecular landscape, which would enable different functioning modes during the night/day cycle, which needs to be taken into account to design drug treatments and time their delivery.
Circadian clock-mediated regulation of blood pressure.
- Biology, PsychologyFree radical biology & medicine
- 2018
Circadian Clock Model Supports Molecular Link Between PER3 and Human Anxiety
- Psychology, BiologyScientific Reports
- 2017
It is shown that two PER3 mutations, a variable number tandem repeat allele and a single-nucleotide polymorphism (SNP), are associated with diurnal preference and higher Trait-Anxiety scores, supporting a role for PER3 in mood modulation.
Alcohol disrupts the central SCN circadian rhythm in rodents and affects expression of clock genes in the brain
- Biology, Medicine
- 2014
The in vitro data show that alcohol stimulates increased Clock and Per2 circadian clock proteins and that siRNA knockdown of these proteins prevents alcohol-induced permeability, and data in human alcoholics show they exhibit abnormal melatonin profiles characteristic of circadian disruption, which support circadian mechanisms for alcohol- induced gut leakiness that could provide new therapeutic targets for ALD.
The Pathophysiologic Role of Disrupted Circadian and Neuroendocrine Rhythms in Breast Carcinogenesis.
- Biology, MedicineEndocrine reviews
- 2016
The importance of the brain-body link through which circadian disruptions contribute to endocrine-dependent diseases, including breast carcinogenesis, by negatively impacting neuroendocrine and neuroimmune cells is examined, and preventive measures directed at maximizing circadian health are considered.
Post-transcriptional control of the mammalian circadian clock: implications for health and disease
- BiologyPflügers Archiv - European Journal of Physiology
- 2016
Recent work implicating regulated mRNA stability, translation and alternative splicing in the control of the mammalian circadian clock, and its role in health and disease is discussed.
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