The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

@article{Klein1990TheTT,
  title={The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain},
  author={R. Klein and D. Conway and L. Parada and M. Barbacid},
  journal={Cell},
  year={1990},
  volume={61},
  pages={647-656}
}
We previously identified two tyrosine protein kinase genes, designated trk and trkB, that code for putative neurogenic cell surface receptors. In this study, we report that the mouse trkB locus codes for at least two classes of receptor-like molecules. These trkB proteins, designated gp145trkB and gp95trkB, have identical extracellular and transmembrane domains, suggesting that they might recognize the same ligand(s). However, only gp145trkB contains a long cytoplasmic region, which includes a… Expand
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  • A. Garner, H. Menegay, +4 authors T. Large
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1996
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The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
TLDR
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Mutational analysis demonstrates that the isoform-specific sequences within the intracellular domains of each receptor are essential for signaling capability, and inhibitor studies suggest that kinases are likely to be involved in the trkB.T1 and tr.T2 signaling pathways. Expand
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In situ hybridization analysis of 14 and 18 day old mouse embryos indicates thattrkB transcripts are localized in the central (CNS) and peripheral (PNS) nervous systems, including brain, spinal cord, spinal and cranial ganglia, paravertebral trunk of the sympathetic nervous system and various innervation pathways, suggesting that trkB may code for a novel cell surface receptor involved in neurogenesis. Expand
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