The trk proto-oncogene product: a signal transducing receptor for nerve growth factor.

@article{Kaplan1991TheTP,
  title={The trk proto-oncogene product: a signal transducing receptor for nerve growth factor.},
  author={David R Kaplan and Barbara L. Hempstead and Dionisio Mart{\'i}n-Zanca and Moses V Chao and Luis F. Parada},
  journal={Science},
  year={1991},
  volume={252 5005},
  pages={554-8}
}
The trk proto-oncogene encodes a 140-kilodalton, membrane-spanning protein tyrosine kinase (p140prototrk) that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of p140prototrk in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that p140prototrk binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar. The identification of… CONTINUE READING
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