The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia.

@article{Thiel2013TheTP,
  title={The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia.},
  author={Austin T Thiel and Zijie Feng and Dhruv K Pant and Lewis A. Chodosh and Xianxin Hua},
  journal={Haematologica},
  year={2013},
  volume={98 6},
  pages={918-27}
}
Trithorax and polycomb group proteins antagonistically regulate the transcription of many genes, and cancer can result from the disruption of this regulation. Deregulation of trithorax function occurs through chromosomal translocations involving the trithorax gene MLL, leading to the expression of MLL fusion proteins and acute leukemia. It is poorly understood how MLL fusion proteins block differentiation, a hallmark of leukemogenesis. We analyzed the effect of acute depletion of menin, a close… CONTINUE READING