The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathways.

@article{Fisher2001TheTT,
  title={The triple threat to nascent apolipoprotein B. Evidence for multiple, distinct degradative pathways.},
  author={Edward A Fisher and Meihui Pan and Xi Chen and Xiaoyan Wu and He M Wang and Haris Jamil and Janet D. Sparks and Kevin J. Williams},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 30},
  pages={27855-63}
}
We previously showed that Omega-3 fatty acids reduce secretion of apolipoprotein B (apoB) from cultured hepatocytes by stimulating post-translational degradation. In this report, we now characterize this process, particularly in regard to the two known processes that degrade newly synthesized apoB, endoplasmic reticulum (ER)-associated degradation and re-uptake from the cell surface. First, we found that Omega-3-induced degradation preferentially reduces the secretion of large, assembled apoB… CONTINUE READING