The triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthma.

@article{Schelfhout2006TheTN,
  title={The triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthma.},
  author={Vanessa J Schelfhout and Renaud Louis and Widukind Lenz and Reinilde Heyrman and Romain Pauwels and Guy Joos},
  journal={Pulmonary pharmacology & therapeutics},
  year={2006},
  volume={19 6},
  pages={413-8}
}
Neurokinin A (NKA) causes bronchoconstriction in asthmatic patients. In vitro both NK1 and NK2 receptors can mediate airway contraction. Moreover in guinea pigs, NK3 receptors facilitate cholinergic neurotransmission. Dual tachykinin NK1/NK2 receptor antagonism results in prevention of NKA-induced bronchoconstriction. We have now examined the effect of a single dose of the triple tachykinin receptor antagonist CS-003 on NKA-induced bronchoconstriction in asthmatics. A double blind, crossover… CONTINUE READING
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The effect of the tachykinin NK 2 receptor antagonist MEN 11420 (nepadutant) on neurokinin A-induced bronchoconstriction in patient s with asthma

  • G Joos, V Schelfhout, V Van De Velde, R. Pauwels
  • Am J Respir Crit Care Med
  • 2001
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