The tripeptide phenylalanine-(d) glutamate-(d) glycine modulates leukocyte infiltration and oxidative damage in rat injured spinal cord

  title={The tripeptide phenylalanine-(d) glutamate-(d) glycine modulates leukocyte infiltration and oxidative damage in rat injured spinal cord},
  author={Feng Bao and Sunil M. John and Y. Chen and Ronald D. Mathison and Lynne C. Weaver},

Effects of a novel tripeptide on neurological outcomes after spinal cord injury

The anti-inflammatory and anti-oxidative actions of feG treatment correlate with improved neurological outcomes after spinal cord injury.

The tripeptide feG inhibits leukocyte adhesion

When administered in vivo, feG prevents inflammation-induced reductions in cell adhesion, as well as restoring its inhibitory effect in vitro, and appears to involve actions on αMβ2 integrin, with a possible interaction with the low affinity FcγRIII receptor (CD16).

Preclinical efficacy of Dexmedetomidine on spinal cord injury provoked oxidative renal damage

Investigation of the potential of α2-adrenoreceptor agonist Dexmedetomidine in ameliorating SCI provoked oxidative renal assault finds that Dex may be a beneficial clinical agent to combat post-SCI renal complications.

Beneficial effects of quercetin on rat urinary bladder after spinal cord injury.

Efficacy of coenzyme Q10 in mitigating spinal cord injury-induced osteoporosis.

Treatment with CoQ10 prevented SCI‑induced bone loss by rescuing the decreased levels of bone mineral density and bone mineral content observed in the SCI rats, and reduced bone malondialdehyde levels with a concomitant increase in superoxide dismutase levels, thus alleviating SCI‐induced oxidative injury.

Ghrelin alleviates s pinal Cord injury in Rats Via its anti-inflammatory Effects Ghrelin Anti-inflamatuar Etkileri Yoluyla Siçanlarda Spinal Kord Hasarini Azaltir

The present study suggests that ghrelin could reduce SCI-induced oxidative stress and exert anti-inflammatory effects in the spinal cord following trauma.



4‐Hydroxynonenal, a Lipid Peroxidation Product, Rapidly Accumulates Following Traumatic Spinal Cord Injury and Inhibits Glutamate Uptake

It is demonstrated that the lipid peroxidation product HNE rapidly accumulates in the spinal cord following injury and that a major consequence of HNE accumulation is a decrease in glutamate uptake, which may potentiate neuronal cell dysfunction and death through excitotoxic mechanisms.

The tripeptide feG reduces endotoxin‐provoked perturbation of intestinal motility and inflammation

It is concluded that feG attenuates both the immediate (intestinal motility) and late (∼ 18 h) inflammatory reactions provoked by endotoxaemia.

Regulation of leukocyte adhesion to heart by the tripeptides feG and feG(NH2).

The inhibition by these tripeptides on neutrophil adhesion to myocytes suggests that salivary glands hormones regulate the severity of cardiac inflammation.

Early anti‐inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats

Data indicate that anti‐CD11d mAb treatment blocks intraspinal neutrophil and macrophage infiltration, reducing the intraspINAL concentrations of reactive oxygen and nitrogen species.

Leukotriene B4 Release and Polymorphonuclear Cell Infiltration in Spinal Cord Injury

Results from this study suggest that the source of leukotriene B4 in spinal cord injury is infiltrating polymorphonuclear cells.

Modulation of neutrophil function by the tripeptide feG

The inhibitory effect of feG on neutrophil movement may be mediated by alterations in the co-stimulatory molecules CD11b and CD16.

Transient Blockade of the CD11d/CD18 Integrin Reduces Secondary Damage after Spinal Cord Injury, Improving Sensory, Autonomic, and Motor Function

The improved neurological recovery after the specific reduction of early inflammation after SCI demonstrates that this selective strategy increases tissue at the injury site and improves its functional capacity.

Review of oxidative stress in brain and spinal cord injury: suggestions for pharmacological and nutritional management strategies.

It is suggested that flavonoids such as quercetin have the potential to be therapeutically effective because of their free radical quenching, iron chelating, and anti-inflammatory properties.