The tripeptide phenylalanine-(d) glutamate-(d) glycine modulates leukocyte infiltration and oxidative damage in rat injured spinal cord

@article{Bao2006TheTP,
  title={The tripeptide phenylalanine-(d) glutamate-(d) glycine modulates leukocyte infiltration and oxidative damage in rat injured spinal cord},
  author={F. Bao and S. John and Y. Chen and R. Mathison and L. Weaver},
  journal={Neuroscience},
  year={2006},
  volume={140},
  pages={1011-1022}
}
  • F. Bao, S. John, +2 authors L. Weaver
  • Published 2006
  • Chemistry, Medicine
  • Neuroscience
    • The tripeptide, phenylalanine-glutamate-glycine (FEG) and its d-isomeric form phenylalanine-(D) glutamate-(D) glycine (feG), derived from submandibular gland peptide-T, significantly reduce the allergic inflammatory response and leukocyte trafficking and neutrophil migration into intestine, heart and lungs. Due to these actions, we hypothesized that feG would attenuate the early inflammatory response to spinal cord injury, reduce free radical production and improve neurological outcomes, like… CONTINUE READING
    View on Elsevier
    doi.org
    36 Citations
    Highly Influential Citations
    1
    Background Citations
    15
    Methods Citations
    1
    36 Citations
    Citation Type

    Citation Type

    Effects of a novel tripeptide on neurological outcomes after spinal cord injury
    • 8
    Montelukast inhibits caspase-3 activity and ameliorates oxidative damage in the spinal cord and urinary bladder of rats with spinal cord injury.
    • 30
    The tripeptide feG inhibits leukocyte adhesion
    • 9
    • PDF
    Preclinical efficacy of Dexmedetomidine on spinal cord injury provoked oxidative renal damage
    • 11
    An integrin inhibiting molecule decreases oxidative damage and improves neurological function after spinal cord injury
    • 25
    Beneficial effects of quercetin on rat urinary bladder after spinal cord injury.
    • 26
    Efficacy of coenzyme Q10 in mitigating spinal cord injury-induced osteoporosis.
    • 7
    • PDF
    Ghrelin alleviates s pinal Cord injury in Rats Via its anti-inflammatory Effects Ghrelin Anti-inflamatuar Etkileri Yoluyla Siçanlarda Spinal Kord Hasarini Azaltir
    Protective effects of melatonin against spinal cord injury induced oxidative damage in rat kidney: A morphological and biochemical study.
    • 14
    Neuroprotective effects of almond skins in experimental spinal cord injury.
    • 17

    References

    SHOWING 1-10 OF 58 REFERENCES
    4‐Hydroxynonenal, a Lipid Peroxidation Product, Rapidly Accumulates Following Traumatic Spinal Cord Injury and Inhibits Glutamate Uptake
    • 180
    The tripeptide feG reduces endotoxin‐provoked perturbation of intestinal motility and inflammation
    • 21
    Regulation of leukocyte adhesion to heart by the tripeptides feG and feG(NH2).
    • 18
    Early anti‐inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats
    • 138
    Leukotriene B4 Release and Polymorphonuclear Cell Infiltration in Spinal Cord Injury
    • 107
    Modulation of neutrophil function by the tripeptide feG
    • 28
    Transient Blockade of the CD11d/CD18 Integrin Reduces Secondary Damage after Spinal Cord Injury, Improving Sensory, Autonomic, and Motor Function
    • 289
    • PDF
    Review of oxidative stress in brain and spinal cord injury: suggestions for pharmacological and nutritional management strategies.
    • 260
    Role of neutrophil elastase in compression-induced spinal cord injury in rats
    • 71
    A monoclonal antibody to CD11d reduces the inflammatory infiltrate into the injured spinal cord: a potential neuroprotective treatment
    • 105