The tripeptide feG reduces endotoxin‐provoked perturbation of intestinal motility and inflammation

@article{Mathison2001TheTF,
  title={The tripeptide feG reduces endotoxin‐provoked perturbation of intestinal motility and inflammation},
  author={Ronald D. Mathison and Pierrette Lo and D. T. M. Tan and Brent Scott and Joseph Davison},
  journal={Neurogastroenterology \& Motility},
  year={2001},
  volume={13}
}
Lipopolysaccharide (LPS)‐induced intestinal endotoxaemia perturbs motility and causes activation and influx of inflammatory cells into the muscle tissue. Because rat submandibular gland peptide T (SGP‐T; Thr‐Asp‐Ile‐Phe‐Glu‐Gly‐Gly), its carboxyl‐terminal fragment tripeptide, FEG (Phe‐Glu‐Gly) and its D‐isomeric analogue, feG, modulate intestinal anaphylactic reactions, we examined whether these peptides also modulate LPS‐induced intestinal endotoxaemia in conscious rats. The disruption of the… 

The tripeptide feG ameliorates systemic inflammatory responses to rat intestinal anaphylaxis

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Small Intestinal Motility

  • W. Hasler
  • Medicine
    Encyclopedia of Gastroenterology
  • 2020

ANTI-INFLAMMATORY ACTIVITY OF HYDROALCOHOLIC EXTRACT OF AERIAL PARTS OF URTICA URENS L.

Hydalcoholic extract of aerial parts of Urtica urens L has significant anti-inflammatory activity in rats induced with formalin, and percentage inhibition shown in group 3 (given extract of 100mg/kg p.o.) and 4 was 69.17% and 72.27%.

Biomedical Research 2003; 14 (1): 30-37

The key evidence leading to the discovery of the CST-SMG axis is summarized and two novel peptides were isolated from the submandibular glands of rats which appear to be the endocrine mediators of this novel immunoregulatory system.

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