The tripartite motif: structure and function.

  title={The tripartite motif: structure and function.},
  author={Lucia Micale and Evelyne Chaignat and Carmela Fusco and Alexandre Reymond and Giuseppe Merla},
  journal={Advances in experimental medicine and biology},
The TRIM/RBCC proteins belong to a family whom members are involved in a variety of cellular processes such as apoptosis and cell cycle regulation. These proteins are defined by the presence of a tripartite motif composed of three zinc-binding domains, a RING finger, one or two B-box motifs, a coiled-coil region and a highly variable C-terminal region. Interestingly, the preserved order of the tripartite motif from the N- to the C-terminal end of the protein and the highly conserved overall… CONTINUE READING

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