The trimeric G protein Go inflicts a double impact on axin in the Wnt/frizzled signaling pathway.

@article{EggerAdam2009TheTG,
  title={The trimeric G protein Go inflicts a double impact on axin in the Wnt/frizzled signaling pathway.},
  author={Diane Egger-Adam and Vladimir L Katanaev},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2009},
  volume={239 1},
  pages={
          168-83
        }
}
The Wnt/Frizzled signaling pathway plays crucial roles in animal development and is deregulated in many cases of carcinogenesis. We and others have previously demonstrated that Frizzled proteins initiating the intracellular signaling are typical G protein-coupled receptors and rely on the trimeric G protein Go for Wnt transduction in Drosophila. However, the mode of action of Go and its interplay with other transducers of the pathway such as Dishevelled and Axin remained unclear. Here we show… CONTINUE READING
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