The triggering receptor expressed on myeloid cells 2 (<ce:italic>TREM2</ce:italic>) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia

@article{Roussos2015TheTR,
  title={The triggering receptor expressed on myeloid cells 2 (<ce:italic>TREM2</ce:italic>) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia},
  author={Panos Roussos and Pavel L. Katsel and Peter S Fam and Weilun Tan and Vahram Haroutunian},
  journal={Alzheimer's & Dementia},
  year={2015},
  volume={11},
  pages={1163-1170}
}
INTRODUCTION The objective of this study was to elucidate the relationship between the triggering receptor expressed on myeloid cells 2 (TREM2) risk variant, neuropathological lesions, alterations in gene and protein expression, and the severity of neuroinflammation. METHODS The genetic association study of the R47 H TREM2 variant with Alzheimer's disease (AD), neuropathology, and changes in TREM2 and TYRO protein tyrosine kinase-binding protein (TYROBP) gene and protein expression, and… CONTINUE READING
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Alzheimer’s disease risk alleles in TREM2 illuminate innate immunity in Alzheimer’s disease

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