The tricarboxylic acid cycle in Dictyostelium discoideum. II. Evaluation of model consistency and robustness.

@article{Shiraishi1992TheTA,
  title={The tricarboxylic acid cycle in Dictyostelium discoideum. II. Evaluation of model consistency and robustness.},
  author={Fumihide Shiraishi and Michael A. Savageau},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 32},
  pages={22919-25}
}
When kinetic models of complex biochemical systems are reconstructed from knowledge of the component reactions that have been characterized in vitro, or when values must be assumed for some of the parameters, errors are invariably encountered, and, as a consequence, the resulting model is frequently internally inconsistent. The simplest and most basic manifestations of such logical inconsistency are the failure of the model to exhibit a steady state or to yield a steady state that is in… CONTINUE READING

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