The trials and tribulations of IL-5, eosinophils, and allergic asthma.

  title={The trials and tribulations of IL-5, eosinophils, and allergic asthma.},
  author={Paul M O'Byrne and Mark D. Inman and Krishnan Parameswaran},
  journal={The Journal of allergy and clinical immunology},
  volume={108 4},
Eosinophils have been suggested to be part of the pathologic process that characterizes asthma, and their recruitment into the upper or lower airways appears to be essential for the clinical manifestations of allergen inhalation. IL-5 is a cytokine necessary for the development, differentiation, recruitment, activation, and survival of eosinophils. Allergen inhalation increases the production of IL-5 in the airways as measured in bronchoalveolar lavage cells and induced sputum. The relationship… CONTINUE READING

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