The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii.

@article{Ngamskulrungroj2009TheTS,
  title={The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii.},
  author={Popchai Ngamskulrungroj and Uwe Himmelreich and Julia A Breger and Christabel Wilson and Methee Chayakulkeeree and Mark B. Krockenberger and Richard Malik and Heide-Marie Daniel and Dena L. Toffaletti and Julianne Teresa Djordjevic and Eleftherios Mylonakis and Wieland Meyer and John R Perfect},
  journal={Infection and immunity},
  year={2009},
  volume={77 10},
  pages={4584-96}
}
The trehalose pathway is essential for stress tolerance and virulence in fungi. We investigated the importance of this pathway for virulence of the pathogenic yeast Cryptococcus gattii using the highly virulent Vancouver Island, Canada, outbreak strain R265. Three genes putatively involved in trehalose biosynthesis, TPS1 (trehalose-6-phosphate [T6P] synthase) and TPS2 (T6P phosphatase), and degradation, NTH1 (neutral trehalose), were deleted in this strain, creating the R265tps1 Delta, R265tps2… CONTINUE READING
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