The tree shrews: adjuncts and alternatives to primates as models for biomedical research

  title={The tree shrews: adjuncts and alternatives to primates as models for biomedical research},
  author={J. Cao and E-B Yang and J J Su and Y. Li and Patricia H Chow},
  journal={Journal of Medical Primatology},
Abstract: The tree shrews are non‐rodent, primate‐like, small animals. There is increasing interest in using them to establish animal models for medical and biological research. This review focuses on the use of the tree shrews in in vivo studies on viral hepatitis, hepatocellular carcinoma (HCC), myopia, and psychosocial stress. Because of the susceptibility of the tree shrews (Tupaia belangeri) and their hepatocytes to infection with human hepatitis B virus (HBV) in vivo and in vitro, these… 

[Tree shrews under the spot light: emerging model of human diseases].

The recent progress in tree shrew biology and the development of tree shrews as human disease models including infectious diseases, metabolic diseases, neurological and psychiatric diseases, and cancers are discussed.

Treeshrews, the primitive primate mammals for medical experimental animals

Small, squirrel-like mammals native to the tropical regions of Southeast Asia, which are placed in Scandentia order including two families, Tupaiidae and Ptilocercidae, treeshrews have been proposed to be used as an alternative experimental animal for nonhuman primates.

The tree shrew as a model for infectious diseases research.

The relatively small size of the tupaia, their homology to humans and their susceptibility to human pathogens make them a useful model for the study of infectious diseases.

Genome of the Chinese tree shrew.

It is demonstrated that tree shrews possess both shared common and unique features, and the genetic basis for the use of this animal as a potential model for biomedical research is provided.

Basal physiological parameters in domesticated tree shrews (Tupaia belangeri chinensis).

The results provided basal physiological indexes for domesticated tree shrews and laid an important foundation for diabetes and stress-related disease models established on tree shrew's.

A tree shrew glioblastoma model recapitulates features of human glioblastoma

The first report of a cancer model mimicking human tumor genetics in tree shrew is presented, and the tree shrew glioma model provides colleagues working in the field of gliomas and cancer in general with a more accurate animal model.

Proteomic characteristics of the liver and skeletal muscle in the Chinese tree shrew (Tupaia belangeri chinensis)

The proteome of liver and muscle tissue in tree the shrew was identified by combining peptide fractionation and LC-MS/MS identification and showed that the tree shrew is closer to primates (human) than to glires (the mouse and rat).

Establishment of the Tree Shrew as an Alcohol-Induced Fatty Liver Model for the Study of Alcoholic Liver Diseases

The established fatty liver model of tree shrews induced by alcohol should be a promising tool for the study of ALDs.

The tree shrew provides a useful alternative model for the study of influenza H1N1 virus

It is proposed that tree shrews could be a useful alternative mammalian model to study pathogenesis of influenza H1N1 virus.

Establishment and transcriptomic features of an immortalized hepatic cell line of the Chinese tree shrew

An immortalized tree shrew hepatic cell line was established, ITH6.1, by introducing the simian virus 40 large T antigen gene into primary tree shrew hepatocytes (PTHs) and it was found that the DNA replication- and cell cycle-related genes were upregulated, whereas the metabolic pathway- related genes were downregulated in early passages of immortalized hepatocytes compared to the PTHs.



Transmission of hepatitis C virus infection to tree shrews.

Psychosocial stress in tree shrews: Clomipramine counteracts behavioral and endocrine changes

Human hepatitis B virus and hepatocellular carcinoma I. Experimental infection of tree shrews with hepatitis B virus

The results successfully establish tree shrews as a reliable and useful animal model for research on HBV infection and its relation to hepatocarcinogenesis.

Reduction of aflatoxin B(1) adduct biomarkers by oltipraz in the tree shrew (Tupaia belangeri chinensis).

Hepatocellular carcinoma in ground squirrels persistently infected with ground squirrel hepatitis virus.

It is suggested that persistent infection with GSHV may also be associated with hepatocellular carcinoma, and the incidence of liver carcinoma reported here in carrier ground squirrels is neither as great as that in carrier woodchucks nor statistically different from the incidence in noncarrier squirrels.

Perspectives on hepatitis B studies with chimpanzees.

Chimpanzees have been shown to be exquisitely susceptible to human hepatitis viruses, without themselves developing clinical illness, thus providing an important model for studies on these agents and providing a means to evaluate the efficacy of virus inactivation strategies.

Hepatitis B virus infection of tupaia hepatocytes in vitro and in vivo

HBV is infectious to tupaia hepatocytes in vitro and transiently in vivo and may become a useful model for the experimental analysis of various molecular and clinical aspects ofHBV infection, including the significance of HBV quasispecies, the steps involved in hepatocarcinogenesis as well as the evaluation of various antiviral strategies.

Efficient Infection of Primary Tupaia Hepatocytes with Purified Human and Woolly Monkey Hepatitis B Virus

It is reported that human serum interferes with HBV binding to the hepatocytes, thus limiting the maximum multiplicity of infection and Purification of HBV virions by gradient sedimentation greatly enhances virus binding and infectivity.

Contribution of aflatoxin B1 and hepatitis B virus infection in the induction of liver tumors in ducks.

A Pekin duck model is used to examine the effect of congenital duck hepatitis B virus infection and aflatoxin B1 exposure in the induction and development of liver cancer and the role of DHBV infection and AFB1 in the etiopathogenesis of liver tumors may help clarify some of the basic mechanisms of carcinogenesis.

Social stress in tree shrews Effects on physiology, brain function, and behavior of subordinate individuals