The tree shrews: adjuncts and alternatives to primates as models for biomedical research

@article{Cao2003TheTS,
  title={The tree shrews: adjuncts and alternatives to primates as models for biomedical research},
  author={J. Cao and E-B Yang and J J Su and Y. Li and Patricia H Chow},
  journal={Journal of Medical Primatology},
  year={2003},
  volume={32}
}
Abstract: The tree shrews are non‐rodent, primate‐like, small animals. There is increasing interest in using them to establish animal models for medical and biological research. This review focuses on the use of the tree shrews in in vivo studies on viral hepatitis, hepatocellular carcinoma (HCC), myopia, and psychosocial stress. Because of the susceptibility of the tree shrews (Tupaia belangeri) and their hepatocytes to infection with human hepatitis B virus (HBV) in vivo and in vitro, these… 

[Tree shrews under the spot light: emerging model of human diseases].

The recent progress in tree shrew biology and the development of tree shrews as human disease models including infectious diseases, metabolic diseases, neurological and psychiatric diseases, and cancers are discussed.

Treeshrews, the primitive primate mammals for medical experimental animals

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The relatively small size of the tupaia, their homology to humans and their susceptibility to human pathogens make them a useful model for the study of infectious diseases.

Genome of the Chinese tree shrew.

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Basal physiological parameters in domesticated tree shrews (Tupaia belangeri chinensis).

The results provided basal physiological indexes for domesticated tree shrews and laid an important foundation for diabetes and stress-related disease models established on tree shrew's.

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The first report of a cancer model mimicking human tumor genetics in tree shrew is presented, and the tree shrew glioma model provides colleagues working in the field of gliomas and cancer in general with a more accurate animal model.

Proteomic characteristics of the liver and skeletal muscle in the Chinese tree shrew (Tupaia belangeri chinensis)

The proteome of liver and muscle tissue in tree the shrew was identified by combining peptide fractionation and LC-MS/MS identification and showed that the tree shrew is closer to primates (human) than to glires (the mouse and rat).

Establishment of the Tree Shrew as an Alcohol-Induced Fatty Liver Model for the Study of Alcoholic Liver Diseases

The established fatty liver model of tree shrews induced by alcohol should be a promising tool for the study of ALDs.

The tree shrew provides a useful alternative model for the study of influenza H1N1 virus

It is proposed that tree shrews could be a useful alternative mammalian model to study pathogenesis of influenza H1N1 virus.

Establishment and transcriptomic features of an immortalized hepatic cell line of the Chinese tree shrew

An immortalized tree shrew hepatic cell line was established, ITH6.1, by introducing the simian virus 40 large T antigen gene into primary tree shrew hepatocytes (PTHs) and it was found that the DNA replication- and cell cycle-related genes were upregulated, whereas the metabolic pathway- related genes were downregulated in early passages of immortalized hepatocytes compared to the PTHs.
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