The treatment of primary childhood acute lymphocytic leukemia with intermediate dose methotrexate.

  title={The treatment of primary childhood acute lymphocytic leukemia with intermediate dose methotrexate.},
  author={Lucius F. Sinks and Jhi Joung Wang and Arnold I. Freeman},
  journal={Haematology and blood transfusion},
Fifty-four consecutive children with acute lymphocytic leukemia (ALL) were treated from August 1974 until December of 1976 at Rosewell Park Memorial Institute (RPMI) according to a protocol which substituted cranial irradiation with systemic intermediate dose methotrexate (IDM) 500 mg/m2 each 3 weeks for a total of 3 courses immediately following induction. Of 54 patients, 52 went into remission (96%). There were 35 standard risk and 17 increased risk patients according to age and presenting… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 29 references

A comparison of four methods of central nervous system prophylaxis in childhood acute lymphoblastie leukemia

  • DM Green, HN Sather, +6 authors E Frei
  • 1980

Abnormal CT scans in asymptomatic children after prophylactic cranial irradiation and intrathecal chemotherapy

  • N Pey-lan-Ramu, DG Poplack, PA Pizzo, BT Adornato, G Dichero
  • N Engl J Med
  • 1978

The critical association between dose fractionation and immunosuppression induced by cranial irradiaton

  • PJ Moe, M Seip
  • 1978

Optimal use of LAsparaginase ( NSC109229 ) in acute lymphocytic leukemia

  • B Jones, JF Holland, +4 authors LF Sinks
  • Med Pediatr Oncol
  • 1977

Radiothe - rapy in leukemia and lymphoma in children

  • D Pinkel, HO Hustu, Aur RJA, K Smith, LD Borella, JV Simone
  • 1977

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