The treatment of patients with aggressive non-Hodgkin's lymphoma.


The curability of the aggressive, large-cell lymphomas was first convincingly reported by Levitt et al in 1972.[1] Patients with “reticulum cell sarcoma” were treated with a regimen that came to be known as COMLA (cyclophosphamide, vincristine [Oncovin], methotrexate, leucovorin, cytarabine [Ara-C]). A more commonly quoted paper was published in 1975 by… (More)


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