The treatment of heart failure: the role of neurohumoral activation.

  title={The treatment of heart failure: the role of neurohumoral activation.},
  author={Holly R. Middlekauff and Allyn L. Mark},
  journal={Internal medicine},
  volume={37 2},
Neurohumoral activation refers to increased activity of the sympathetic nervous system, renin-angiotensin system, vasopressin and atrial natriuretic peptide. It is now known that neurohumoral activation contributes to the transition from ventricular dysfunction to clinical heart failure, and is an independent predictor of poor prognosis in heart failure. Although the treatment of heart failure has traditionally focused on drugs to improve ventricular function, there is increasing evidence that… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 22 extracted citations

Overexpression of eNOS in brain stem reduces enhanced sympathetic drive in mice with myocardial infarction.

American journal of physiology. Heart and circulatory physiology • 2005
View 5 Excerpts
Highly Influenced

Endogenous angiotensin II in the NTS contributes to sympathetic activation in rats with aortocaval shunt.

American journal of physiology. Regulatory, integrative and comparative physiology • 2001
View 7 Excerpts
Highly Influenced

Heart failure readmissions.

Current treatment options in cardiovascular medicine • 2013

Central neural control of sympathetic nerve activity in heart failure following exercise training.

American journal of physiology. Heart and circulatory physiology • 2012
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 61 references

Effects of chronic ACE inhibition on sympathetic nerve traffic and baroreflex control of circulation in heart failure

Y Takeishi, H Atsumi, S Fujiwara, K Takahashi, H Tomoike
Circulation • 1997

Predictors of response to exercise training in severe chronic congestive heart failure

K Meyer, Schwaibold Gornandt L
AmJ Cardiol • 1997

Randomizedtrial oflosartan versus captopril in patients over 65 with heart failure ( Evaluation ofLosartan in the Elderly Study , ELITE )

F Waagstein, A Hjalmarson, E Varnauskas, I Wallentin
Lancet • 1997

The effect of digoxin on mortality and morbidity in patients with heart failure

Thames, LA Waickman, FM Abboud
New Engl J Med • 1997

Similar Papers

Loading similar papers…