The treatment of chilblains with nifedipine: the results of a pilot study, a double‐blind placebo‐controlled randomized study and a long‐term open trial

@article{Rustin1989TheTO,
  title={The treatment of chilblains with nifedipine: the results of a pilot study, a double‐blind placebo‐controlled randomized study and a long‐term open trial},
  author={Malcolm H. A. Rustin and Julia A. Newton and Neil P. Smith and Pauline M. Dowd},
  journal={British Journal of Dermatology},
  year={1989},
  volume={120}
}
A pilot study, a double‐blind placebo‐controlled randomised study and a long term open trial have indicated that nifedipine is effective in the treatment of perniosis. At a dose of 20 mg to 60 mg daily, nifedipine significantly reduced the time to clearance of existing lesions and prevented the development of new chilblains. Nifedipine also reduced the pain, soreness and irritation of the lesions. A comparison of the pre‐and post‐treatment skin biopsies showed resolution of the dermal oedema… Expand
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TLDR
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