The trascriptional activation of the human copper/zinc superoxide dismutase gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin through two different regulator sites, the anitoxidant responsive element and xenobiotic responsive element

@article{Park2002TheTA,
  title={The trascriptional activation of the human copper/zinc superoxide dismutase gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin through two different regulator sites, the anitoxidant responsive element and xenobiotic responsive element},
  author={Eun Young Park and Hyune Mo Rho},
  journal={Molecular and Cellular Biochemistry},
  year={2002},
  volume={240},
  pages={47-55}
}
Cu/Zn superoxide dismutase (SOD1) catalyzes the dismutation of superoxide radicals produced during biological oxidations and environmental stress. The most toxic dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), induces SOD1 in human liver cells. Deletion analyses showed that the promoter region between −400 and −239 was responsible for the induction, in which two different characteristic regulatory elements, the antioxidant responsive element (ARE) and xenobiotic responsive element (XRE… CONTINUE READING

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