The transsulfuration pathway: a source of cysteine for glutathione in astrocytes

@article{McBean2011TheTP,
  title={The transsulfuration pathway: a source of cysteine for glutathione in astrocytes},
  author={Gethin J. McBean},
  journal={Amino Acids},
  year={2011},
  volume={42},
  pages={199-205}
}
Astrocyte cells require cysteine as a substrate for glutamate cysteine ligase (γ-glutamylcysteine synthase; EC 6.3.2.2) catalyst of the rate-limiting step of the γ-glutamylcycle leading to formation of glutathione (l-γ-glutamyl-l-cysteinyl-glycine; GSH). In both astrocytes and glioblastoma/astrocytoma cells, the majority of cysteine originates from reduction of cystine imported by the x c − cystine-glutamate exchanger. However, the transsulfuration pathway, which supplies cysteine from the… CONTINUE READING

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