The transmission disequilibrium test suggests that HLA-DR4 and DR13 are linked to autism spectrum disorder.

@article{Torres2002TheTD,
  title={The transmission disequilibrium test suggests that HLA-DR4 and DR13 are linked to autism spectrum disorder.},
  author={Anthony R. Torres and Alma Maciulis and E Gene Stubbs and Adele Cutler and Dennis Odell},
  journal={Human immunology},
  year={2002},
  volume={63 4},
  pages={311-6}
}
We have evaluated possible contributions of HLA-DRB1 alleles to autism spectrum disorder (ASD) in 103 families of Caucasian descent. The DR4 allele occurred more often in probands than controls (0.007), whereas the DR13,14 alleles occurred less often in probands than controls (p = 0.003). The transmission disequilibrium test (TDT) indicated that the ASD probands inherited the DR4 allele more frequently than expected (p = 0.026) from the fathers. The TDT also revealed that fewer DR13 alleles… CONTINUE READING

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