The transmembrane region of the nicotinic acetylcholine receptor: is it an all-helix bundle?

Abstract

The nicotinic acetylcholine receptor is the best characterised member of the Ligand-Gated-Ion-Channel family of receptors. In spite of a wealth of data from molecular cloning studies these receptors have so far eluded all attempts at crystallisation; quantitative structural data are few and are at relatively low resolution. The widely accepted current model… (More)

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