The transmembrane protein-tyrosine phosphatase CD45 is associated with decreased insulin receptor signaling.

@article{Kulas1996TheTP,
  title={The transmembrane protein-tyrosine phosphatase CD45 is associated with decreased insulin receptor signaling.},
  author={D T Kulas and Gregory G Freund and Robert A Mooney},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 2},
  pages={755-60}
}
Overexpression of the transmembrane protein-tyrosine phosphatase (PTPase) CD45 in nonhematopoietic cells results in decreased signaling through growth factor receptor tyrosine kinases. Consistent with these data, insulin receptor signaling is increased when the CD45-related PTPase LAR is reduced by antisense suppression in a rat hepatoma cell line. To test whether the hematopoietic cell-specific PTPase CD45 functions in a manner similar to LAR by negatively modulating insulin receptor signaling… CONTINUE READING
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Overexpression of the transmembrane protein - tyrosine phosphatase ( PTPase ) CD45 in nonhematopoietic cells results in decreased signaling through growth factor receptor tyrosine kinases .
Overexpression of the transmembrane protein - tyrosine phosphatase ( PTPase ) CD45 in nonhematopoietic cells results in decreased signaling through growth factor receptor tyrosine kinases .
Overexpression of the transmembrane protein - tyrosine phosphatase ( PTPase ) CD45 in nonhematopoietic cells results in decreased signaling through growth factor receptor tyrosine kinases .
Insulin - dependent tyrosine phosphorylation of insulin receptor substrate 1 ( IRS-1 ) and Shc was 3-fold greater in CD45- cells .
While expression of CD45 was associated with a decrease in the responsiveness of early insulin receptor signaling , interleukin 6-dependent activation of mitogen - activated protein kinase kinase and mitogen - activated protein kinase was equivalent between CD45- and CD45 + cells .
While expression of CD45 was associated with a decrease in the responsiveness of early insulin receptor signaling , interleukin 6-dependent activation of mitogen - activated protein kinase kinase and mitogen - activated protein kinase was equivalent between CD45- and CD45 + cells .
While expression of CD45 was associated with a decrease in the responsiveness of early insulin receptor signaling , interleukin 6-dependent activation of mitogen - activated protein kinase kinase and mitogen - activated protein kinase was equivalent between CD45- and CD45 + cells .
While expression of CD45 was associated with a decrease in the responsiveness of early insulin receptor signaling , interleukin 6-dependent activation of mitogen - activated protein kinase kinase and mitogen - activated protein kinase was equivalent between CD45- and CD45 + cells .
While expression of CD45 was associated with a decrease in the responsiveness of early insulin receptor signaling , interleukin 6-dependent activation of mitogen - activated protein kinase kinase and mitogen - activated protein kinase was equivalent between CD45- and CD45 + cells .
Insulin - dependent tyrosine phosphorylation of insulin receptor substrate 1 ( IRS-1 ) and Shc was 3-fold greater in CD45- cells .
Insulin - dependent tyrosine phosphorylation of insulin receptor substrate 1 ( IRS-1 ) and Shc was 3-fold greater in CD45- cells .
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