The transmembrane domains of hepatitis C virus envelope glycoproteins E1 and E2 play a major role in heterodimerization.

@article{beeck2000TheTD,
  title={The transmembrane domains of hepatitis C virus envelope glycoproteins E1 and E2 play a major role in heterodimerization.},
  author={Anne Op de beeck and Roland Montserret and Sandrine Duvet and Laurence Cocquerel and Ren{\'e} Cacan and B Barberot and Marc le Maire and François Penin and Jean Dubuisson},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 40},
  pages={31428-37}
}
Oligomerization of viral envelope proteins is essential to control virus assembly and fusion. The transmembrane domains (TMDs) of hepatitis C virus envelope glycoproteins E1 and E2 have been shown to play multiple functions during the biogenesis of E1E2 heterodimer. This makes them very unique among known transmembrane sequences. In this report, we used alanine scanning insertion mutagenesis in the TMDs of E1 and E2 to examine their role in the assembly of E1E2 heterodimer. Alanine insertion… CONTINUE READING

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