The transmembrane domains of Sindbis virus envelope glycoproteins induce cell death.

@article{Joe1998TheTD,
  title={The transmembrane domains of Sindbis virus envelope glycoproteins induce cell death.},
  author={Andrew K. Joe and Hong Foo and Lindsay. Kleeman and Beth Levine},
  journal={Journal of virology},
  year={1998},
  volume={72 5},
  pages={3935-43}
}
Sindbis virus, the prototype alphavirus, kills cells by inducing apoptosis. To investigate potential mechanisms by which Sindbis virus induces apoptosis, we examined whether specific viral gene products were able to induce cell death. Genes encoding the three structural proteins--capsid, the precursor E1 (6K plus E1), and the precursor E2 (P62 or E3 plus E2)--were cotransfected with a beta-galactosidase reporter plasmid in transient-transfection assays in rat prostate adenocarcinoma AT3 cells… CONTINUE READING
17 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…