The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho.

Abstract

The transmembrane adaptor protein NTAL (non-T-cell activation linker) participates in signalosome assembly in hematopoietic cells, but its exact role in cell physiology remains enigmatic. We report here that BM-derived mast cells from NTAL-deficient mice, responding to Ag alone or in combination with SCF, exhibit reduced spreading on fibronectin, enhanced… (More)
DOI: 10.1002/eji.201040403

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