The translocation mechanism of P-glycoprotein.

  title={The translocation mechanism of P-glycoprotein.},
  author={Richard Callaghan and Robert Curtis Ford and Ian D Kerr},
  journal={FEBS letters},
  volume={580 4},
Multidrug transporters are involved in mediating the failure of chemotherapy in treating several serious diseases. The archetypal multidrug transporter P-glycoprotein (P-gp) confers resistance to a large number of chemically and functionally unrelated anti-cancer drugs by mediating efflux from cancer cells. The ability to efflux such a large number of drugs remains a biological enigma and the lack of mechanistic understanding of the translocation pathway used by P-gp prevents rational design of… CONTINUE READING

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