The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome.

@article{Kasai1997TheTR,
  title={The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome.},
  author={Michiyuki Kasai and Takashi Matsuzaki and Katsuo Katayanagi and Akira Omori and Richard T Maziarz and Jack Leonard Strominger and Kazuma Aoki and Kazushi Suzuki},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 17},
  pages={11402-7}
}
We previously showed that consensus sequences exist at the chromosomal breakpoints in lymphoid malignancies and that these sequences are specifically recognized by a novel DNA binding protein, Translin. In the present study, the native form of Translin was established to be a ring-shaped structure by electron microscopy and crystallographic studies. It was also determined that this multimeric Translin formed by the subunits is responsible for its binding to target sequences situated only at… CONTINUE READING
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