The translational landscape of the mammalian cell cycle.

@article{Stumpf2013TheTL,
  title={The translational landscape of the mammalian cell cycle.},
  author={Craig R. Stumpf and Melissa V. Moreno and Adam B. Olshen and Barry S. Taylor and Davide Ruggero},
  journal={Molecular cell},
  year={2013},
  volume={52 4},
  pages={574-82}
}
Gene regulation during cell-cycle progression is an intricately choreographed process, ensuring accurate DNA replication and division. However, the translational landscape of gene expression underlying cell-cycle progression remains largely unknown. Employing genome-wide ribosome profiling, we uncover widespread translational regulation of hundreds of mRNAs serving as an unexpected mechanism for gene regulation underlying cell-cycle progression. A striking example is the S phase translational… CONTINUE READING
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