The translational landscape of mTOR signalling steers cancer initiation and metastasis

@article{Hsieh2012TheTL,
  title={The translational landscape of mTOR signalling steers cancer initiation and metastasis},
  author={Andrew C. Hsieh and Yi Liu and Merritt P. Edlind and Nicholas T Ingolia and Matthew R. Janes and Annie Sher and Evan Y. Shi and Craig R. Stumpf and Carly Christensen and Michael J. Bonham and Shunyou Wang and Pingda Ren and Michael Martin and Katti A Jessen and Morris E. Feldman and Jonathan S. Weissman and Kevan M. Shokat and Christian Rommel and Davide Ruggero},
  journal={Nature},
  year={2012},
  volume={485},
  pages={55-61}
}
The mammalian target of rapamycin (mTOR) kinase is a master regulator of protein synthesis that couples nutrient sensing to cell growth and cancer. However, the downstream translationally regulated nodes of gene expression that may direct cancer development are poorly characterized. Using ribosome profiling, we uncover specialized translation of the prostate cancer genome by oncogenic mTOR signalling, revealing a remarkably specific repertoire of genes involved in cell proliferation, metabolism… CONTINUE READING
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