The translation of drug efficacy from in vivo models to human disease with special reference to experimental autoimmune encephalomyelitis and multiple sclerosis

@article{Bolton2007TheTO,
  title={The translation of drug efficacy from in vivo models to human disease with special reference to experimental autoimmune encephalomyelitis and multiple sclerosis},
  author={Christopher Bolton},
  journal={Inflammopharmacology},
  year={2007},
  volume={15},
  pages={183-187}
}
  • C. Bolton
  • Published 2007
  • Medicine
  • Inflammopharmacology
Abstract.The search for new drugs to treat human disease is strongly reliant on the use of in vivo animal models to generate pre-clinical data. However, drug efficacy in experimental disease models does not often translate effectively to the human condition. Multiple sclerosis (MS) is a disease of the human central nervous system that has features duplicated in the animal model experimental autoimmune encephalomyelitis (EAE). Many compounds have shown activity in EAE and some have progressed to… Expand
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