The translation of drug efficacy from in vivo models to human disease with special reference to experimental autoimmune encephalomyelitis and multiple sclerosis

@article{Bolton2007TheTO,
  title={The translation of drug efficacy from in vivo models to human disease with special reference to experimental autoimmune encephalomyelitis and multiple sclerosis},
  author={C. Bolton},
  journal={Inflammopharmacology},
  year={2007},
  volume={15},
  pages={183-187}
}
  • C. Bolton
  • Published 2007
  • Medicine
  • Inflammopharmacology
  • Abstract.The search for new drugs to treat human disease is strongly reliant on the use of in vivo animal models to generate pre-clinical data. However, drug efficacy in experimental disease models does not often translate effectively to the human condition. Multiple sclerosis (MS) is a disease of the human central nervous system that has features duplicated in the animal model experimental autoimmune encephalomyelitis (EAE). Many compounds have shown activity in EAE and some have progressed to… CONTINUE READING
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    References

    SHOWING 1-10 OF 70 REFERENCES
    The value of animal models for drug development in multiple sclerosis.
    • 142
    • PDF
    How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis
    • 456
    • PDF
    Models of multiple sclerosis: new insights into pathophysiology and repair
    • 87
    Multiple Sclerosis and Glutamate
    • 102
    Suppression of the hyperacute form of experimental allergic encephalomyelitis by drugs.
    • 28
    Experimental allergic encephalomyelitis: A misleading model of multiple sclerosis
    • 231
    • PDF
    The effect of cyclosporin A on the adoptive transfer of experimental allergic encephalomyelitis in the Lewis rat.
    • 54
    Glutamate Receptors in Neuroinflammatory Demyelinating Disease
    • 68
    • PDF
    Suppression of acute and relapsing experimental allergic encephalomyelitis with mitoxantrone.
    • 76