The translation factor eIF5A and human cancer.

  title={The translation factor eIF5A and human cancer.},
  author={Michael B. Mathews and John W. B. Hershey},
  journal={Biochimica et biophysica acta},
  volume={1849 7},
The eukaryotic initiation factor eIF5A is a translation factor that, unusually, has been assigned functions in both initiation and elongation. Additionally, it is implicated in transcription, mRNA turnover and nucleocytoplasmic transport. Two eIF5A isoforms are generated from distinct but related genes. The major isoform, eIF5A1, is considered constitutive, is abundantly expressed in most cells, and is essential for cell proliferation. The second isoform, eIF5A2, is expressed in few normal… CONTINUE READING


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Rodnina, EF-P is essential for rapid synthesis of proteins containing consecutive proline

  • L. K. Doerfel, I.Wohlgemuth, C. Kothe, F. Peske, M.V.H. Urlaub
  • residues, Science
  • 2013
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