The transition state for folding of an outer membrane protein.

@article{Huysmans2010TheTS,
  title={The transition state for folding of an outer membrane protein.},
  author={Gerard H. M. Huysmans and Stephen A. Baldwin and David J Brockwell and Sheena E Radford},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 9},
  pages={4099-104}
}
Inspired by the seminal work of Anfinsen, investigations of the folding of small water-soluble proteins have culminated in detailed insights into how these molecules attain and stabilize their native folds. In contrast, despite their overwhelming importance in biology, progress in understanding the folding and stability of membrane proteins remains relatively limited. Here we use mutational analysis to describe the transition state involved in the reversible folding of the beta-barrel membrane… CONTINUE READING
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