The transition of microglia to a ramified phenotype is associated with the formation of stable acetylated and detyrosinated microtubules.

@article{Ilschner1996TheTO,
  title={The transition of microglia to a ramified phenotype is associated with the formation of stable acetylated and detyrosinated microtubules.},
  author={S. Ilschner and Richard E. Brandt},
  journal={Glia},
  year={1996},
  volume={18 2},
  pages={
          129-40
        }
}
In situ and in vitro, microglia can have different morphologies, which are thought to reflect distinct physiological activities. Two extreme forms are ameboid and ramified microglia. To study cytoskeletal changes during differentiation, we used defined cell culture systems to yield cultures of ameboid or ramified microglia from mouse brain. With respect to proliferation, secretion, receptor-expression, and phagocytosis, ramified microglia was generally less active. We found that the transition… CONTINUE READING

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