The transition between transcriptional initiation and elongation in E. coli is highly variable and often rate limiting.

@article{Reppas2006TheTB,
  title={The transition between transcriptional initiation and elongation in E. coli is highly variable and often rate limiting.},
  author={Nikos B. Reppas and Joseph T Wade and George M. Church and Kevin Struhl},
  journal={Molecular cell},
  year={2006},
  volume={24 5},
  pages={747-757}
}
We perform a genome-wide analysis of the transition between transcriptional initiation and elongation in Escherichia coli by determining the association of core RNA polymerase (RNAP) and the promoter-recognition factor sigma70 with respect to RNA transcripts. We identify 1286 sigma70-associated promoters, including many internal to known operons, and demonstrate that sigma70 is usually released very rapidly from elongating RNAP complexes. On average, RNAP density is higher at the promoter than… CONTINUE READING
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