The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels.

@article{Singh2010TheTR,
  title={The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels.},
  author={Amrit Singh and Michael E. Hildebrand and Esperanza Garc{\'i}a and Terrance P. Snutch},
  journal={British journal of pharmacology},
  year={2010},
  volume={160 6},
  pages={1464-75}
}
BACKGROUND AND PURPOSE SKF96365 (SKF), originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels. While SKF has been used as a tool to define the functional roles of TRPC channels in various cell and tissue types, there are notable overlapping physiological and pathophysiological associations between TRPC channels and low-voltage-activated (LVA) T-type calcium channels. The… CONTINUE READING

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